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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Gossypol, BRD4770
Phytochemical Name Gossypol (PubChem CID: 3503 )
Anticancer drug Name BRD4770 (PubChem CID: 72193870 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 466
Ref_1
Pair Name Gossypol, BRD4770
Disease Info [ICD-11: 2C10.Z] Pancreatic cancer Investigative
Biological Phenomena Induction-->Autophagy
Gene Regulation Up-regulation Phosphorylation TP53 hsa7157
Up-regulation Expression MAP1LC3B hsa81631
Up-regulation Expression BNIP3 hsa664
In Vitro Model PANC-1 Pancreatic ductal adenocarcinoma Homo sapiens (Human) CVCL_0480
Result The combination of gossypol and BRD4770 increased LC3-II levels and the autophagosome number in PANC-1 cells, and the compound combination appears to act in a BNIP3 (B-cell lymphoma 2 19-kDa interacting protein)-dependent manner, suggesting that these compounds act together to induce autophagy-related cell death in pancreatic cancer cells.
03. Reference
No. Title Href
1 Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis. 2013 Jun 27;4(6):e690. doi: 10.1038/cddis.2013.191. Click
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